Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow
نویسندگان
چکیده
منابع مشابه
The blood-brain barrier. Transport across the cerebral endothelium.
THE ORIGINAL idea of a blood-brain barrier arose at the turn of the century as an explanation of the properties of the living brain in relation to certain dyes and pharmacologically active compounds, injected either into the bloodstream or directly into the cerebrospinal fluid (CSF) of experimental animals (reviewed by Bradbury, 1979). This developed into the general concept of a cellular barri...
متن کاملTransport across the Cerebral Endothelium
THE ORIGINAL idea of a blood-brain barrier arose at the turn of the century as an explanation of the properties of the living brain in relation to certain dyes and pharmacologically active compounds, injected either into the bloodstream or directly into the cerebrospinal fluid (CSF) of experimental animals (reviewed by Bradbury, 1979). This developed into the general concept of a cellular barri...
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Determination of sizes and flexibilities of RNA molecules is important in understanding the nature of packing in folded structures and in elucidating interactions between RNA and DNA or proteins. Using the coordinates of the structures of RNA in the Protein Data Bank we find that the size of the folded RNA structures, measured using the radius of gyration R(G), follows the Flory scaling law, na...
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Therapeutic and diagnostic nanomaterials are being intensely studied for several diseases, including cancer and atherosclerosis. However, the exact mechanism by which nanomedicines accumulate at targeted sites remains a topic of investigation, especially in the context of atherosclerotic disease. Models to accurately predict transvascular permeation of nanomedicines are needed to aid in design ...
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ژورنال
عنوان ژورنال: Bioengineering & Translational Medicine
سال: 2019
ISSN: 2380-6761,2380-6761
DOI: 10.1002/btm2.10153